Recognising these crucial requirements, Prosonix generates drug particles from fundamental principles that are specifically designed at the particle level to meet the criteria required for orally inhaled respiratory medicines, such as:
- Consistent and predictable particles
- Assured formulation performance (stable, drug-only formulations possible, no need for excipients)
- Facilitates precise, localised drug targeting
- Enables use of simple, cost-effective devices
- Enables development of Multi-component Particles™
Prosonix achieves this sophisticated level of control over the physicochemical properties of drug particles via an integrated platform of unique and proprietary particle engineering technologies and formulation processes. This platform is based on the use of ultrasound to control the crystallization process (sonocrystallization) of drug particles.
Prosonix believes its approach to designing and developing respiratory medicines is radical compared to the conventional approach where large particles are crushed into small particles via a jet-milling process. Prosonix also believes that its particle engineering approach has the potential to avoid the formulation, stability, dose variability and delivery issues that result from using jet-milled drug material.
Prosonix’ technology has broad applicability - independent of product class, indication or device - and is proven at commercial scale.